Here’s the inside scoop on the myriad of studies demonstrating the safety and effectiveness of antimicrobial silver.

For years the naysayers have claimed there’s no modern clinical evidence for the safety or effectiveness of colloidal silver and other forms of antimicrobial silver. Even the FDA makes this spurious claim.

But the truth is, clinical studies on the safety and effectiveness of numerous forms of antimicrobial silver – including colloidal silver – are abundant. You just have to know where to look. And thankfully, the internet makes it easy to find these supposedly non-existent studies, and share them with others.

Here’s the inside scoop on the myriad of studies demonstrating the safety and effectiveness of antimicrobial silver.

Here, for example, is a study, demonstrating that a typical ionic colloidal silver product similar to those found in most health food stores is not in the least bit toxic to human cells:

1. An In Vitro Toxicity Study of a Colloid Silver Health Product and Atomic Quantum Clusters of Silver and Gold (Ionosil Study)

The colloidal silver demonstrated zero toxicity…zero DNA damage…and zero inflammation! – google image 

Skeptics continuously claim colloidal silver and other forms of antimicrobial silver are toxic to human cells.

In fact, hardly a week goes by that I don’t see this claim being made by medical doctors and their bureaucratic counterparts, or by environmentalists, so-called “quackbusters” and other notorious naysayers.

So in this in vitro clinical study conducted in June 2007 at The Faculty of Pharmaceutical Sciences, Copenhagen University, the researcher set out to discover whether or not a specific brand of colloidal silver known as Ionosil (i.e., Sweden’s leading brand of colloidal silver) is toxic to human cells.

The researcher compared the effects of Ionosil to atomic gold and silver quantum clusters on human cells, looking for cytotoxicity (i.e. cell damage), inflammation and DNA damage.

And guess what? The colloidal silver demonstrated zero toxicity…zero DNA damage…and zero inflammation!

Amazing, isn’t it?

In short, the science demonstrates precisely what colloidal silver users have known for decades, i.e., colloidal silver has a superb toxicological safety profile.

Which is to say, when used correctly it’s no more toxic than any other natural mineral supplement on the face of the earth!

2. An Evaluation of the safety and effectiveness of Colloidal Silver Nanoparticles

Naysayers and skeptics also continuously claim that colloidal silver and other forms of antimicrobial silver are toxic to little critters in the environment.

In this study, researchers tested mice and guinea pigs using a staggering 5,000 ppm colloidal silver nanoparticles (i.e., extremely tiny particles of colloidal silver).

The researchers were looking to see if the colloidal silver caused acute oral toxicity, eye irritation, corrosion or dermal toxicity.

But after 24, 48 and 72 hours of exposure to these super-high levels of antimicrobial silver, blood chemistry analysis and other tests showed no differences in any of the parameters examined.

In other words, there were no significant differences in the health and well-being of the mice and guinea pigs treated with 5,000 ppm colloidal silver, versus the mice and guinea pigs that were not treated with colloidal silver.

According to the researchers “There was neither any gross lesion nor histopathological change observed in various organs.” In other words, there was no significant organ or tissue damage from these wildly excessive levels of colloidal silver.


The researchers also concluded that colloidal silver nanoparticles administered orally or topically to the little animals at a whopping 5,000 ppm appear to be relatively safe.

When you consider that most people are considerably larger than mice and guinea pigs (at least, I am), but tend to use colloidal silver in comparatively very low concentrations of only 10 to 20 ppm, you can understand the significance of this very important new study!

3. Silver Colloidal Nanoparticles: Antifungal Effect Against Adhered Cells and Biofilms of Candida albicans and Candida glabrata

In this 2011 study, researchers demonstrate that colloidal silver nanoparticles not only have a profound antifungal effect on two forms of Candida yeast, but are also effective in destroying the biofilms produced by these fungal pathogens.

Biofilms, of course, allow pathogens to adhere to cell walls inside the body and form colonies that are largely protected from the human immune system as well as from any natural predators such as your body’s beneficial bacteria. You can think of a biofilms as a fortified castle for microbes.

Indeed, in many cases biofilms are what stymie modern prescription drug-based therapies from actually getting to the pathogen, because the drugs can’t penetrate the biofilm barrier.

Thankfully, colloidal silver nanoparticles seem to have no problem whatsoever busting through these protective fungal biofilms to get at the disease-causing pathogens!

4. Silver Nanoparticles as Potential Antiviral Agents

Silver Nanoparticles as Potential Antiviral Agents – google image 

The above study is a clinical review from the science journal Molecules. In it, researchers review a number of studies demonstrating the potent antiviral effects of silver nanoparticles.

Indeed, as the review points out, a growing number of in vitro studies have found antimicrobial silver to be effective against HIV-1, hepatitis B virus, herpes simplex virus, respiratory syncytial virus and even monkey pox virus.

The study concludes that silver and other metal nanoparticles “may provide opportunity to develop novel antiviral therapies with lower levels of resistance compared to conventional antiviral drugs.”

Gee…ya think?

5. Silver Nano – A Trove for Retinal Therapies

Eye disease can be debilitating. But silver nanoparticles are being discovered to have profound therapeutic properties in certain diseases of the eyes that can result in visual impairment or even irreversible blindness.

This clinical study review shows that silver nanoparticles may play a successful role in reversing pathological retinal angiogenesis, one of the most feared complications among diseases of the retina.

According to the study authors, “Recent findings made by us on therapeutic applications of biologically synthesized silver nanoparticles (AgNPs) against VEGF induced retinal endothelial cells, elucidates the effectual inhibitory activities of AgNPs over the downstream signaling pathways (Src and AKT/PI3K) leading to retinal angiogenesis.”

In plain English, that means antimicrobial silver stops the progression of the eye disease dead in its tracks. The researchers concluded that present clinical research “consequently affirms the futuristic application of silver nanoparticles as a boon to ocular therapies.”

Well, considering the fact that I’m getting to that age where my eyes don’t work quite as well as they used to, I certainly look forward to these new silver-based eye therapies!

Meanwhile, I just spray a tiny bit of colloidal silver into my eyes each morning with a glass pump spray bottle with a fine mist head on it, and guess what? No more itchy, scratchy eyes, and no more of those painful sties. Sweet!


6. Topical Delivery of Silver Nanoparticles Promotes Wound Healing

In this animal study using mice, the researchers investigated the wound-healing properties of silver nanoparticles and found that “rapid healing and improved cosmetic appearance occur in a dose-dependent manner.”

In other words, the wounded mice treated with silver nanoparticles not only healed more quickly than the controls, but the scarring was significantly improved also. And the more silver nanoparticles used, the better the healing turned out!

The researchers stated, “…through quantitative PCR, immunohistochemistry, and proteomic studies, we showed that silver nanoparticles exert positive effects through their antimicrobial properties, reduction in wound inflammation, and modulation of fibrogenic cytokines.”

In other words, the silver nanoparticles prevented infection in the wounds, and reduced inflammation by decreasing negative aspects of the healing process.

The researchers conclude:

“These results have given insight into the actions of silver and have provided a novel therapeutic direction for wound treatment in clinical practice.”

Well, that’s nice. Very nice.

But of course, the wound healing properties of colloidal silver have been known all of the way back to the late 1800’s when medical practitioners found that surgical wounds closed up with sutures made of fine silver wire tended to heal much faster than normal sutures. What’s more, the surgical wounds failed to become infected.

7. Antifungal Effect of Silver Nanoparticles on Dermatophytes

Here’s an interesting clinical study demonstrating the effectiveness of antimicrobial silver against the pathogen most commonly responsible for toenail fungus. According to the study authors:

“Spherical silver nanoparticles (nano-Ag) were synthesized and their antifungal effects on fungal pathogens of the skin were investigated.

Nano-Ag showed potent activity against clinical isolates and ATCC strains of Trichophyton mentagrophytes and Candida species.”

Of course, for decades women have been using oral doses of colloidal silver to heal vaginal Candida yeast infections.

And numerous colloidal silver users attest to the fact that colloidal silver obliterates topical yeast infections such as toenail fungus and athlete’s foot, as well.

So, once again, it’s nice to see modern science catching up with the past!


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